diff --git a/de4dot.code/deobfuscators/dotNET_Reactor/v4/Deobfuscator.cs b/de4dot.code/deobfuscators/dotNET_Reactor/v4/Deobfuscator.cs
index 59cb0b46..ec0b2a6c 100644
--- a/de4dot.code/deobfuscators/dotNET_Reactor/v4/Deobfuscator.cs
+++ b/de4dot.code/deobfuscators/dotNET_Reactor/v4/Deobfuscator.cs
@@ -345,8 +345,14 @@ namespace de4dot.code.deobfuscators.dotNET_Reactor.v4 {
 					return DeobfuscatorInfo.THE_NAME + " 4.1";
 				return DeobfuscatorInfo.THE_NAME + " 4.0";
 			}
-			if (!hasCorEnableProfilingString)
-				return DeobfuscatorInfo.THE_NAME + " 4.x";
+			if (!hasCorEnableProfilingString) {
+				// 4.x or 4.5
+				bool callsReverse = DotNetUtils.callsMethod(methodsDecrypter.Method, "System.Void System.Array::Reverse(System.Array)");
+				if (!callsReverse)
+					return DeobfuscatorInfo.THE_NAME + " 4.x";
+				return DeobfuscatorInfo.THE_NAME + " 4.5";
+			}
+
 			// 4.2-4.4
 
 			if (!localTypes.exists("System.Byte&"))
diff --git a/de4dot.code/deobfuscators/dotNET_Reactor/v4/EncryptedResource.cs b/de4dot.code/deobfuscators/dotNET_Reactor/v4/EncryptedResource.cs
index 60bbda7b..490ba263 100644
--- a/de4dot.code/deobfuscators/dotNET_Reactor/v4/EncryptedResource.cs
+++ b/de4dot.code/deobfuscators/dotNET_Reactor/v4/EncryptedResource.cs
@@ -116,6 +116,8 @@ namespace de4dot.code.deobfuscators.dotNET_Reactor.v4 {
 			iv = ArrayFinder.getInitializedByteArray(resourceDecrypterMethod, 16);
 			if (iv == null)
 				throw new ApplicationException("Could not find resource decrypter IV");
+			if (needReverse())
+				Array.Reverse(iv);	// DNR 4.5.0.0
 			if (usesPublicKeyToken()) {
 				var publicKeyToken = module.Assembly.PublicKeyToken;
 				if (publicKeyToken != null && publicKeyToken.Data.Length > 0) {
@@ -146,6 +148,10 @@ namespace de4dot.code.deobfuscators.dotNET_Reactor.v4 {
 			return false;
 		}
 
+		bool needReverse() {
+			return DotNetUtils.callsMethod(resourceDecrypterMethod, "System.Void System.Array::Reverse(System.Array)");
+		}
+
 		EmbeddedResource findMethodsDecrypterResource(MethodDef method) {
 			foreach (var s in DotNetUtils.getCodeStrings(method)) {
 				var resource = DotNetUtils.getResource(module, s) as EmbeddedResource;
diff --git a/de4dot.code/deobfuscators/dotNET_Reactor/v4/MethodsDecrypter.cs b/de4dot.code/deobfuscators/dotNET_Reactor/v4/MethodsDecrypter.cs
index d0588984..83390106 100644
--- a/de4dot.code/deobfuscators/dotNET_Reactor/v4/MethodsDecrypter.cs
+++ b/de4dot.code/deobfuscators/dotNET_Reactor/v4/MethodsDecrypter.cs
@@ -168,7 +168,7 @@ namespace de4dot.code.deobfuscators.dotNET_Reactor.v4 {
 				}
 			}
 			else {
-				// DNR 4.0 - 4.4 (jitter is hooked)
+				// DNR 4.0 - 4.5 (jitter is hooked)
 
 				var methodDef = peImage.DotNetFile.MetaData.TablesStream.MethodTable;
 				var rvaToIndex = new Dictionary<uint, int>((int)methodDef.Rows);
diff --git a/de4dot.code/deobfuscators/dotNET_Reactor/v4/NativeImageUnpacker.cs b/de4dot.code/deobfuscators/dotNET_Reactor/v4/NativeImageUnpacker.cs
index a87b8a32..e7cea77b 100644
--- a/de4dot.code/deobfuscators/dotNET_Reactor/v4/NativeImageUnpacker.cs
+++ b/de4dot.code/deobfuscators/dotNET_Reactor/v4/NativeImageUnpacker.cs
@@ -22,11 +22,13 @@ using System.IO;
 using ICSharpCode.SharpZipLib.Zip.Compression;
 using dot10.PE;
 using dot10.IO;
+using dot10.DotNet;
 
 namespace de4dot.code.deobfuscators.dotNET_Reactor.v4 {
 	class NativeImageUnpacker {
 		MyPEImage peImage;
 		bool isNet1x;
+		const int loaderHeaderSizeV45 = 14;
 
 		public NativeImageUnpacker(IPEImage peImage) {
 			this.peImage = new MyPEImage(peImage);
@@ -60,18 +62,44 @@ namespace de4dot.code.deobfuscators.dotNET_Reactor.v4 {
 					return null;
 			}
 
-			if (BitConverter.ToInt16(inflatedData, 0) != 0x5A4D)
-				return null;
+			// CLR 1.x or DNR v4.0 - v4.4
+			if (BitConverter.ToInt16(inflatedData, 0) == 0x5A4D)
+				return inflatedData;
 
-			return inflatedData;
+			// DNR v4.5
+			if (BitConverter.ToInt16(inflatedData, loaderHeaderSizeV45) == 0x5A4D)
+				return unpackLoader(inflatedData);
+
+			return null;
 		}
 
-		static uint[] baseOffsets = new uint[] {
+		static byte[] unpackLoader(byte[] loaderData) {
+			var loaderBytes = new byte[loaderData.Length - loaderHeaderSizeV45];
+			Array.Copy(loaderData, loaderHeaderSizeV45, loaderBytes, 0, loaderBytes.Length);
+
+			try {
+				using (var asmLoader = ModuleDefMD.Load(loaderBytes)) {
+					if (asmLoader.Resources.Count == 0)
+						return null;
+					var resource = asmLoader.Resources[0] as EmbeddedResource;
+					if (resource == null)
+						return null;
+
+					return resource.Data.ReadAllBytes();
+				}
+			}
+			catch {
+				return null;
+			}
+		}
+
+		static readonly uint[] baseOffsets = new uint[] {
 			0x1C00,	// DNR 4.0 & 4.1
 			0x1900,	// DNR 4.2.7.5
-			0x1B60,	// DNR 4.2.8.4, 4.3 & 4.4
+			0x1B60,	// DNR 4.2.8.4, 4.3, 4.4, 4.5
+			0x700,	// DNR 4.5.0.0
 		};
-		static short[] decryptMethodPattern = new short[] {
+		static readonly short[] decryptMethodPattern = new short[] {
 			/* 00 */	0x83, 0xEC, 0x38,		// sub     esp, 38h
 			/* 03 */	0x53,					// push    ebx
 			/* 04 */	0xB0, -1,				// mov     al, ??h
@@ -84,7 +112,7 @@ namespace de4dot.code.deobfuscators.dotNET_Reactor.v4 {
 			/* 1C */	0x55,					// push    ebp
 			/* 1D */	0x56,					// push    esi
 		};
-		static short[] startMethodNet1xPattern = new short[] {
+		static readonly short[] startMethodNet1xPattern = new short[] {
 			/* 00 */ 0x55,						// push    ebp
 			/* 01 */ 0x8B, 0xEC,				// mov     ebp, esp
 			/* 03 */ 0xB9, 0x14, 0x00, 0x00, 0x00, // mov  ecx, 14h